Virtual lines, a deadlock-free and real-time routing mechanism for ATM networks

In this paper, we present a routing mechanism and buffer allocation mechanism for an ATM switching fabric. Since the fabric will be used to transfer multimedia traffic, it should provide a guaranteed throughput and a bounded latency. We focus on the design of a suitable routing mechanism that is capable of fulfilling these requirements and is free of deadlocks. We will describe two basic concepts that can be used to implement deadlock-free routing. Routing of messages is closely related to buffering. We have organized the buffers into parallel FIFO's, each representing a virtual line. In this way, we not only have solved the problem of head of line blocking, but we can also give real-time guarantees. We will show that for local high-speed networks, it is more advantageous to have a proper flow control than to have large buffers. Although the virtual line concept can have a low buffer utilization, the transfer efficiency can be higher. The virtual line concept allows adaptive routing. The total throughput of the network can be improved by using alternative routes. Adaptive routing is attractive in networks where alternative routes are not much longer than the initial route(s). The network of the switching fabric is built up from switching elements interconnected in a Kautz topology

Virtual lines, a deadlock free and real-time routing mechanism for ATM networks

In this paper we present a routing mechanism and buffer allocation mechanism for an ATM switching fabric. Since the fabric will be used to transfer multimedia traffic it should provide a guaranteed throughput and a bounded latency. We focus on the design of a suitable routing mechanism that is capable to fulfil these requirements and is free of deadlocks. We will describe two basic concepts that can be used to implement deadlock free routing. Routing of messages is closely related to buffering. We have organized the buffers into parallel fifos, each representing a virtual line. In this way we not only have solved the problem of Head Of Line blocking, but we can also give real-time guarantees. We will show that for local high-speed networks it is more advantageous to have a proper flow control than to have large buffers. Although the virtual line concept can have a low buffer utilization, the transfer efficiency can be higher. The virtual lines concept allows adaptive routing. The total throughput of the network can be improved by using alternative routes. Adaptive routing is attractive in networks where alternative routes are not much longer than the initial route(s). The network of the switching fabric is built up from switching elements interconnected in a Kautz topology

The VICI-trial: high frequency oscillation versus conventional mechanical ventilation in newborns with congenital diaphragmatic hernia: an international multicentre randomized controlled trial

Background: Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly of the diaphragm resulting in pulmonary hypoplasia and pulmonary hypertension. It is associated with a high risk of mortality and pulmonary morbidity. Previous retrospective studies have reported high frequency oscillatory ventilation (HFO) to reduce pulmonary morbidity in infants with CDH, while others indicated HFO to be associated with worse outcome. We therefore aimed to develop a randomized controlled trial to compare initial ventilatory treatment with high-frequency oscillation and conventional ventilation in infants with CDH.Methods/design: This trial is designed as a multicentre trial in which 400 infants (200 in each arm) will be included. Primary outcome measures are BPD, described as oxygen dependency by day 28 according to the definition of Jobe and Bancalari, and/or mortality by day 28. All liveborn infants with CDH born at a gestational age of over 34 weeks and no other severe congenital anomalies are eligible for inclusion. Parental informed consent is asked antenatally and the allocated ventilation mode starts within two hours after birth. Laboratory samples of blood, urine and tracheal aspirate are taken at the first day of life, day 3, day 7, day 14 and day 28 to evaluate laboratory markers for ventilator-induced lung injury and pulmonary hypertension.Discussion: To date, randomized clinical trials are lacking in the field of CDH. The VICI-trial, as the first randomized clinical trial in the field of CDH, may provide further insight in ventilation strategies in CDH patient. This may hopefully prevent mortality and morbidity.Trial registration: Netherlands Trial Register (NTR): NTR1310

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lines, a deadlock free and real-time routin

Characterization of human iodothyronine sulfotransferases

Sulfation is an important pathway of thyroid hormone metabolism that facilitates the degradation of the hormone by the type I iodo-thyronine deiodinase, but little is known about which human sulfo-transferase isoenzymes are involved. We have investigated the sul-fation of the prohormone T4, the active hormone T3, and the metabolites rT3 and 3,39-diiodothyronine (3,39-T2) by human liver and kidney cytosol as well as by recombinant human SULT1A1 and SULT1A3, previously known as phenol-preferring and monoamine-preferring phenol sulfotransferase, respectively. In all cases, the sub-strate preference was 3,39-T2.. rT3. T3. T4. The apparent Km values of 3,39-T2 and T3 [at 50 mmol/L 39-phosphoadenosine-59-phos-phosulfate (PAPS)] were 1.02 and 54.9 mmol/L for liver cytosol, 0.64 and 27.8 mmol/L for kidney cytosol, 0.14 and 29.1 mmol/L for SULT1A1, and 33 and 112 mmol/L for SULT1A3, respectively. Th

Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters

Polyhalogenated aromatic hydrocarbons (PHAHs), such as polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenylethers, and bisphenol A derivatives are persistent environmental pollutants, which are capable of interfering with reproductive and endocrine function in birds, fish, reptiles, and mammals. PHAHs exert estrogenic effects that may be mediated in part by their hydroxylated metabolites (PHAH-OHs), the mechanisms of which remain to be identified. PHAH-OHs show low affinity for the ER. Alternatively, they may exert their estrogenic effects by inhibiting E2 metabolism. As sulfation of E2 by estrogen sulfotransferase (SULT1E1) is an important pathway for E2 inactivation, inhibition of SULT1E1 may lead to an increased bioavailability of estrogens in tissues expressing this enzyme. Therefore, we studied the possible inhibition of human SULT1E1 by hydroxylated PHAH metabolites and the sulfation of the different compounds by SULT1E1. We found marked inhibition of SULT1E1 by various PHAH-OHs, in particular by compounds with two adjacent halogen substituents around the hydroxyl group that were effective at (sub)nanomolar concentrations. Depending on the structure, the inhibition is primarily competitive or noncompetitive. Most PHAH-OHs are also sulfated by SULT1E1. We also investigated the inhibitory effects of the various PHAH-OHs on E2 sulfation by human liver cytosol and found that the effects were strongly correlated with their inhibitions of recombinant SULT1E1 (r = 0.922). Based on these results, we hypothesize that hydroxylated PHAHs exert their estrogenic effects at least in part by inhibiting SULT1E1-catalyzed E2 sulfation